Quikclot vs Celox vs XGauze

celox vs xgauzeEvery healthcare agent knows how important haemostatic agents are in attending to injured patients. In part they help to control bleeding from wounded spots; they also speed up the natural clotting process of the body as they apply pressure either inside or on the wound.

Haemostatic agents further help in controlling bleeding as a supporting agent to tourniquets, compression bandages, Israeli bandages, etc. or in regions of the body where these cannot be applied. Often used in shoulder and hip injuries, haemostatic agents are invaluable to first aid.

Initially made to be used in the military, haemostatic agents are now widely available for everyday use. That is why you will be able to find one in most first aid kits in different households. Quikclot, Celox, and XGauze are all types of haemostatic agents that are readily available for use.

What should you know about them and which should top your list when restocking your first aid kit?  This article is exactly what you need to guide you in making the best decision but first, let’s describe the formation process of blood clotting.

The Blood Clotting Process

A series of reactions takes place when a blood vessel is broken or cut. These reactions break the platelets, making them stick to the blood vessel’s edges. The platelets, in turn, release other chemicals that commence the blood clotting mechanisms.

Often described as a cascade, the formation of blood clots stems from platelets, which activate other platelets on opening. This hastens up the process of blood clot formation until the hole of the wound is filled.

First Aid Haemostatic Agents

Managing bleeding is instrumental in saving lives, especially when it is excessive and spiraling out of control. Such severe cases of bleeding make it even more logical that each first aid kit houses a military-grade clotting agent. Minor cuts may not require the use of haemostatic agents as applying pressure with a normal gauze will do the trick, and eventually save money in the long run. Still, when the injury is severe, you need something more powerful to rise to the occasion and this involves packing the wound and applying pressure.

Haemostatic agents are made in different forms of gauze, sponges, and granules. All of these have proven to be effective, but the z-folded gauze is renowned to be the most versatile amongst the bunch. Making use of granules creates a mess, which can easily be eliminated by making use of the gauze, which has the haemostatic agent enmeshed in it. The gauze can be used in packing irregularly-shaped wounds in ways that a sponge cannot. The gauze can be used in wrapping head injuries, amputations, and injuries to areas that cannot be packed.

When compared to the old-style rolls, z-fold works even better. Old-style rolls are quite difficult to hold and often fall while unraveling, this is not the case with the z-gauze which will not likely pick up dirt as it would unlikely fall. Additionally, the z-gauze has a strip that can be detected by doctors using an x-ray, which prevents them from being accidentally left inside the body.


QuikclotMarketed as Quikclot, Quick clotting bandages are used to address occurrences of major bleeding as they clot blood in faster ways than the body will without the haemostatic agent. It is popularly used in the US military and it was negatively received in the past for releasing a lot of heat on contact with blood. The excessive heat was produced as a result of the chemical used. This is no longer the case, as the company has reinvented itself and found a better alternative. In recent times, Quikclot has adopted the use of kaolin, a natural and hypoallergenic clotting agent responsible for speeding up the normal blood clotting response of the body. As you would expect, this newly improved version of the haemostatic agent does not release heat on contact with blood. Quikclot has a strong reputation as a solid and reliable product, earmarking its wide use in both Afghanistan and Iraq in the military.

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CeloxCelox is another haemostatic agent brand. This over-the-counter clotting agent delivers fast first aid treatment to all bleeding types such as scrapes, cuts, nose bleeding, and other types of severe bleeding. It has proven to be effective in the presence of blood-thinning agents. Celox makes use of a different clotting agent, which is opposed to the use of Kaolin.

Chitosan, obtained from shellfish is the active clotting agent in Celox. This clotting agent takes the form of a tiny bead, having a high surface area. On exposure to blood, a gel-like clot is created on the surface of the injury as an expansion of the beads occurs. This gel-like clot is responsible for the flow of blood. No heat is produced by Celox on interacting with blood. Instead, its components are broken down in the body, even though it is applied externally.

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XGauze is relatively new to the scene as a first-aid agent. Even though it has not spent as much time as others, such as Quikclot and Celox, it has proven to be effective. On contact with liquid, this haemostatic agent, packed with absorptive mini-sponges in small sizes, grows 10 times in size. It is packed on an injury in a similar way to Quikclot and Celox. What makes XGauze even more remarkable is that it stops the bleeding of an injury faster than Celox and Quikclot. This is largely as a result of the advantage that an expanding micro-sponge has over traditional methods of haemorrhage control. Nevertheless, direct pressure remains the oldest and quickest way to control the bleeding of a wounded site as the pressure uses the underlying bone to close the blood vessel.

Pressure is applied to the blood vessels by the expanding micro-sponges from within an injured site. This ensures that even irregular injuries such as that from gunshots and torso injuries are handled properly as the sponges fill the corners of the hole of the wound. You can also expect injuries that cannot be compressed by any bone to be treated with ease.

Unlike the others, XGauze does not employ the use of haemostatic agents to speed up the clotting process. The extra surface area enables it to clot quicker than normal gauze.

Summarily, Celox and Quikclot make use of extra ingredients to speed up the clotting of blood. XGauze does the same, but it takes a different method to do so. As a newbie on the scene, it is yet to undergo the same level of field test as the rest, despite the promising results being suggested by various lab reports.

Still, XGauze is not without faults. One of its potential disadvantages is that it has limited use for amputations, medium-sized wounds or other external wounds as the expanding gauze is designed for packing wounds. Making use of tourniquets is better for handling amputations, and a vet-bond surgical skin glue is a cheaper option when tending to medium-sized wounds.

How Haemostatic Agents Reach With Blood Clotting Disorders

Sometimes, the clotting of blood does not take place as we expect it to. This is largely a result of some conditions or genetic disorders including blood thinners, haemophilia, and hypothermic bleeding conditions, which slow down the process of clotting. Here is how Celox, Quikclot, and XGauze react to the body under these conditions.

Blood thinners

Blood thinners are used in the treatment of cardiovascular issues such as heart diseases. They include warfarin, aspirin, and heparin. Quikclot and Celox have both been confirmed to work when patients are on blood thinners. Based on its action mechanism, XGauze also seems likely to work.


Affecting about 1/5000 persons, haemophilia is a genetic blood clotting disorder that prevents the formation of a clot as a result of a shortage in some factors needed for the process to take place. Small cuts experienced by persons with this disorder can be a very serious issue. Persons with haemophilia often take prescribed clotting factors to aid the process in cases of emergency.

Both XGauze and Quikclot have not been confirmed to be tested on haemophiliacs, but Celox works well regardless of the blood disorder. It has been tried and tested to be effective. XGauze will likely work as a result of its working mechanism, which allows the expanding sponges to put pressure on the vessel of the blood. Still, it will not work if the natural clot mechanism is broken. Quikclot activates the natural clotting mechanism of the body and will likely not work under haemophilic conditions.

Hypothermic Bleeding

Hypothermia increases the time taken for blood to clot. Celox and Quikclot have been tested to work under this condition. There is less information available to suggest that XGauze will prove to be effective under such conditions, but it is more likely for it to work as well when considering its action mechanism.


There is no doubt that these haemostatic agents are useful as emergency aids to stop bleeding. Quikclot and Celox makes use of natural agents to speed up the process, and they are both tried and tested under different conditions. XGauze, a new member of the block is effective as well, but most of its information is based on lab analysis. Celox seems to have an edge as it tested to work under any condition of blood disorder. Regardless of this, all three products do a great job of stopping the bleeding from sores. This makes it hard to choose Celox vs Quikclot vs XGauze.

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